References for the Neuroinflammatory Series by Marco can be found on this page
Are people with ME/CFs caught in a self-perpetuating vicious neuroinflammatory cycle?
- Not Fatigue After All? New Model Suggests Other Symptoms Better Explain Chronic Fatigue Syndrome (ME/CFS)
- Glutamate – One More Piece in the Chronic Fatigue Syndrome (ME/CFS) Puzzle? The Neuroinflammatory Series Pt. II
- “Does A Rare Neurological Disorder Provide Clues to ME/CFS and FM? The Neuroinflammation Series Pt IIIa “
- The Immune in Neuroimmune: Cytokines, Bugs and NK Cells – Part IV of the Neuroinflammatory Series Continues
References
Neurometabolic Functioning and Neuropsychological Correlates in Children With ADHD-H: Preliminary Findings Helen Courvoisie, M.D.; Stephen R. Hooper, Ph.D.; Camille Fine, Ph.D.; Lester Kwock, Ph.D.; Mauricio Castillo, M.D.http://neuro.psychiatryonline.org/article.aspx?articleid=101853
Glutamate and dopamine components in schizophrenia. Philip Seeman http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647567
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis Cross-Disorder Group of the Psychiatric Genomics Consortium http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2812%2962129-1/fulltext
Same Genetic Basis Found in 5 Types of Mental Disorders Gina Kolata, New York Times, 28 February, 2013 http://www.nytimes.com/2013/03/01/health/study-finds-genetic-risk-factors-shared-by-5-psychiatric-disorders.html?_r=0
Novel glutamatergic agents for major depressive disorder and bipolar disorder. Machado-Vieira R, Ibrahim L, Henter ID, Zarate CA Jr.http://www.ncbi.nlm.nih.gov/pubmed/21971560
The role of glutamate in anxiety and related disorders. Cortese BM, Phan KL. http://www.ncbi.nlm.nih.gov/pubmed/16400245
Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment. Pittenger C, Bloch MH, Williams K. http://www.ncbi.nlm.nih.gov/pubmed/21963369
Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord Zhen Guo, Congling Zhao, Menggui Huang, Tianwen Huang, Mingran Fan, Zhiqin Xie, Ying Chen, Xiaolin Zhao, Guannan Xia, Junlan Geng, and Leping Cheng. http://www.jneurosci.org/content/32/25/8509.abstract
Increased glutamate/glutamine compounds in the brains of patients with fibromyalgia: a magnetic resonance spectroscopy study.Valdés M, Collado A, Bargalló N, Vázquez M, Rami L, Gómez E, Salamero M. http://www.ncbi.nlm.nih.gov/pubmed/20191578
Evaluation of the efficacy of memantine in the treatment of fibromyalgia: stuy protocol for a doubled-blind randomized controlled trial with six-mont follow-up. Bárbara Olivan-Blázquez, Marta Puebla, Bárbara Masluk, Mari-Cruz Pérez-Yus, Raquel Arcega, Eva Andrés, Yolanda López-del-Hoyo, Rosa Magallon, Miquel Roca, Javier Garcia-Campayo http://www.trialsjournal.com/content/pdf/1745-6215-14-3.pdf
Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects. Y. Lin, K. Roman, K. D. Foust, B. K. Kaspar, M. T. Bailey, and R. L. Stephen. http://www.hindawi.com/journals/prt/2011/507029/
Differential dynamics of amino acid release in the amygdala and olfactory cortex during odor fear acquisition as revealed with simultaneous high temporal resolution microdialysis. Chloé Hegoburu, Yannick Sevelinges, Marc Thévenet, Rémi Gervais, Sandrine Parrot and Anne-Marie Mou. http://learnmem.cshlp.org/content/16/11/687.full
NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity. MARTIN L. PALL http://www.fasebj.org/content/16/11/1407.long
Central hypersensitivity in chronic pain: mechanisms and clinical implications. Curatolo M, Arendt-Nielsen L, Petersen-Felix S. http://www.ncbi.nlm.nih.gov/pubmed/16616268
Chronic pain alters DNA marking in the brain. McGill University Newsroom. http://www.mcgill.ca/newsroom/channels/news/chronic-pain-alters-dna-marking-brain-225012
Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome. Alison Beaumont, Alexander R. Burton, Jim Lemon, Barbara K. Bennett, Andrew Lloyd, Uté Vollmer-Conna. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049518
Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies. Murugan K. Ravindran, Oluwatoyin Adewuyi, Yin Zheng, Rakib U. Rayhan, Uyenphuong Le, Christian R. Timbol, Samantha Merck, Rania Esteitie, Michelle Cooney, Charles Read & James N. Baraniuk. http://www.ccsenet.org/journal/index.php/gjhs/article/view/22240/14809
Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Licht CM, de Geus EJ, Zitman FG, Hoogendijk WJ, van Dyck R, Penninx BW. http://www.ncbi.nlm.nih.gov/pubmed/19047522
Reduced heart rate variability and vagal tone in anxiety: trait versus state, and the effects of autogenic training. Miu AC, Heilman RM, Miclea M. http://www.ncbi.nlm.nih.gov/pubmed/19059813
Depression, Comorbid Anxiety Disorders, and Heart Rate Variability in Physically Healthy, Unmedicated Patients: Implications for Cardiovascular Risk. Andrew H. Kemp, Daniel S. Quintana, Kim L. Felmingham, Slade Matthews, Herbert F. Jeline http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030777
Reduced heart rate variability predicts poor sleep quality in a case-control study of chronic fatigue syndrome. Burton AR, Rahman K, Kadota Y, Lloyd A, Vollmer-Conna U. http://www.ncbi.nlm.nih.gov/pubmed/20502886
Molecular Pathomechanisms and New Trends in Drug Research Chapter 6. Heat Shock Proteins. Peter Csermely and Ichiro Yahar. https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&sqi=2&ved=0CDQQFjAA&url=http%3A%2F%2Fwww.chaperone.sote.hu%2F02taylor-francis.PDF&ei=tTwOUcn6KcSo0AXAnoGgDg&usg=AFQjCNHoYRk0MTpUPOzW_wlJOoYH2AUtkg&sig2=Zuwsm9iTedM6Yl0gl3UYbg
Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls. Anita A. Thambirajah BSc. Kenna Sleigh RN, MSN, PhD. H. Grant Stiver MD, FRCPC. Anthony W. Chow MD, FACP, FRCPC. http://www.ncbi.nlm.nih.gov/pubmed/190329
Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. Jammes Y, Steinberg JG, Delliaux S, Brégeon F. http://www.ncbi.nlm.nih.gov/pubmed/19457057
Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins. Jammes Y, Steinberg JG, Delliaux S. http://www.ncbi.nlm.nih.gov/pubmed/22112145
Time course and differential responses of the major heat shock protein families in human skeletal muscle following acute nondamaging treadmill exercise. James P. Morton, Don P. M. MacLaren, Nigel T. Cable, Thomas Bongers, Richard D. Griffiths, Iain T. Campbell, Louise Evans, Anna Kayani, Anne McArdle, and Barry Drust. http://jap.physiology.org/content/101/1/176.full
Myalgic Encephalomyelitis – Adult & Paediatric: International Consensus Primer for Medical Practitioners. Carruthers, van de Sande. https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&ved=0CEIQFjAC&url=http%3A%2F%2Fwww.hetalternatief.org%2FICC%2520primer%25202012.pdf&ei=dE8FUfC_LIuN0wWO5IDIDg&usg=AFQjCNFGhtVtkcLWAmn3JxPYz8AQNiZqzA&sig2=L7aFRJtiTk0jyi0F7xudsg
Heat shock protein HSP70 increases the resistance of cortical cells to glutamate excitotoxicity. Mokrushin AA, Pavlinova LI, Plekhanov AYhttp://www.ncbi.nlm.nih.gov/pubmed/1625460
Heat shock proteins and virus replication: hsp70s as mediators of the antiviral effects of prostaglandins. Santoro MG. http://www.ncbi.nlm.nih.gov/pubmed/7988663
Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Papadopoulos AS, Cleare AJ.http://www.ncbi.nlm.nih.gov/pubmed/21946893
Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis – a review. Heesen C, Gold SM, Huitinga I, Reul JM. http://www.ncbi.nlm.nih.gov/pubmed/1760284
Synaptic regulation of the hypothalamic–pituitary–adrenal axis and its modulation by glucocorticoids and stress. Benjamin H. Levy and Jeffrey G. Tasker. http://europepmc.org/articles/PMC3349941/
Stress-induced priming of glutamate synapses unmasks associative short-term plasticity. J Brent Kuzmiski, Vincent Marty, Dinara V Baimoukhametova & Jaideep S Bains. http://www.nature.com/neuro/journal/v13/n10/full/nn.2629.html
Role of GABA and Glutamate Circuitry in Hypothalamo-Pituitary-Adrenocortical Stress Integration JAMES P. HERMAN, NANCY K. MUELLER, HELMER FIGUEIREDO http://onlinelibrary.wiley.com/doi/10.1196/annals.1296.004/abstract
Pharmacotherapy of post-traumatic stress disorder. Ravindran LN, Stein MB. http://faculty.washington.edu/ekanter/Ravindran.pdf
Does the Chronic Fatigue Syndrome Involve the Autonomic Nervous System? Roy Freeman, MD, , Anthony L. Komaroff, MD. http://www.sciencedirect.com/science/article/pii/S000293439700087
Symptoms of autonomic dysfunction in chronic fatigue syndrome. J.L. NEWTON, O. OKONKWO, K. SUTCLIFFE, A. SETH, J. SHIN and D.E.J. JONES. http://128.121.104.17/MESA/Newton.pd
Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome. Alison Beaumont, Alexander R. Burton, Jim Lemon, Barbara K. Bennett, Andrew Lloyd, Uté Vollmer-Conna. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049518
Small fibers in fibromyalgia syndrome. Nurcan Üçeyler, Daniel Zeller, Ann-Kathrin Kahn, Susanne Kewenig, Sarah Kittel-Schneider, Annina Schmid, Jordi Casanova-Molla, Karlheinz Reiners, Claudia Sommer. http://www.uni-wuerzburg.de/en/sonstiges/meldungen/detail/artikel/fibromyalg/
Autonomic neuropathy. Neuropathy – autonomic; Autonomic nerve disease Pubmed Heath. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001780/
Autonomic Neuropathy. Patient.co.uk. http://www.patient.co.uk/doctor/autonomic-neuropathy
Diabetic cardiovascular autonomic neuropathy: clinical implications. Karayannis G, Giamouzis G, Cokkinos DV, Skoularigis J, Triposkiadis F. http://www.ncbi.nlm.nih.gov/pubmed/22894631
A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives. Derrick Lonsdale. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1375232/
Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions.
Zhang SX, Weilersbacher GS, Henderson SW, Corso T, Olney JW, Langlais PJ. http://www.ncbi.nlm.nih.gov/pubmed/7876893
Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes
Alan S. Hazell, Pierre Pannunzio, K.V. Rama Rao, David V. Pow, Andrea Rambald http://onlinelibrary.wiley.com/doi/10.1002/glia.10241/abstract
Wernicke’s Encephalopathy Wikipedia http://en.wikipedia.org/wiki/Wernicke%27s_encephalopathy#Signs_and_symptoms
Does the chronic fatigue syndrome involve the autonomic nervous system? Freeman R, Komaroff AL. http://www.ncbi.nlm.nih.gov/pubmed/9217617
Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation Jiabao He, Kieren G. Hollingsworth, Julia L. Newton, Andrew M. Blamirea http://www.sciencedirect.com/science/article/pii/S2213158212000484
Tinnitus: Is This What Happens When the Brain’s Gatekeeper Breaks Down? NIH – National Institute on Deafness and other Communication Disorders http://www.nidcd.nih.gov/news/releases/11/pages/031611.aspx
Dysregulation of limbic and auditory networks in tinnitus. Leaver AM, Renier L, Chevillet MA, Morgan S, Kim HJ, Rauschecker JP. http://www.ncbi.nlm.nih.gov/pubmed/21220097
Revisiting Baclofen for the Treatment of Severe Chronic Tinnitus Paul F. Smith, Yiwen Zheng, and Cynthia L. Darlington http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297816/
Safety of Intratympanic Injection of AM-101 in Patients with Acute Inner Ear Tinnitus Muehlmeier G. · Biesinger E. · Maier H. http://www.karger.com/Article/FullText/322641
References For “Does A Rare Neurological Disorder Provide Clues to ME/CFS and FM? The Neuroinflammation Series“
Stiff person syndrome. Duddy ME, Baker MR. http://www.ncbi.nlm.nih.gov/pubmed/19349711
Stiff Person Syndrome
Wikipedia
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http://www.ninds.nih.gov/disorders/stiffperson/stiffperson.htm
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Joseph L. Whelan, MD
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IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.
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Blood Brain Barrier – The Role of GAD Antibodies in Psychiatry
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Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Cross-Disorder Group of the Psychiatric Genomics Consortium
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Stiff Person Syndrome Medscape Reference
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References For “Not Fatigue After All? New Model Suggests Other Symptoms Better Explain Chronic Fatigue Syndrome (ME/CFS)”
Phenomenological Dimensions of Sensory Gating
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Cancer-Related Fatigue – Epidemiology, Pathogenesis, Diagnosis, and Treatment
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The Comorbidity of Self-Reported Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder, and Traumatic Symptoms
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Möller M, Du Preez JL, Emsley R, Harvey BH.
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Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington’s disease.
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Transcriptional control of energy homeostasis through the PGC1 coactivators
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Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes.
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The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice
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N-acetyl cysteine as a glutathione precursor for schizophrenia–a double-blind, randomized, placebo-controlled trial.
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Moderate exercise increases expression for sensory, adrenergic and immune genes in chronic fatigue syndrome patients, but not in normal subjects
Alan R. Light,1,2 Andrea T. White,3 Ronald W. Hughen,1 and Kathleen C. Light1
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Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome
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Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
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Identification and Treatment of Symptoms Associated with Inflammation in Medically Ill Patients
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Sex Hormones in Autism: Androgens and Estrogens Differentially and Reciprocally Regulate RORA, a Novel Candidate Gene for Autism
Tewarit Sarachana, Minyi Xu, Ray-Chang Wu, Valerie W. Hu
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A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
M W Logue, C Baldwin, G Guffanti, E Melista, E J Wolf, A F Reardon, M Uddin, D Wildman, S Galea, K C Koenen and M W Miller
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Could glutamate excitotoxicity be a key player in chronic fatigue syndrome?
References For Glutamate – One More Piece in the Chronic Fatigue Syndrome (ME/CFS) Puzzle? The Neuroinflammatory Series Pt. II
Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.
Maloney EM, Boneva RS, Lin JM, Reeves WC.
http://www.ncbi.nlm.nih.gov/pubmed/20102774
The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic β-Cells and Prevents Glutamate-induced β-Cell Death*
Eliana S. Di Cairano, Alberto M. Davalli, Lucia Perego, Silvia Sala, V. Franca Sacchi, Stefano La Rosa‖, Giovanna Finzi‖, Claudia Placidi‖, Carlo Capella‖, Paola Conti, Victoria E. Centonze, Francesca Casiraghi, Federico Bertuzzi, Franco Folli and Carla Perego
http://www.jbc.org/content/286/16/14007.full
The relationship between bipolar disorder and type 2 diabetes: More than just co-morbid disorders.
Calkin CV, Gardner DM, Ransom T, Alda M.
http://www.ncbi.nlm.nih.gov/pubmed/22621171
Maternal Metabolic Conditions and Risk for Autism and Other Neurodevelopmental Disorders
Paula Krakowiak, MS, Cheryl K. Walker, MD, Andrew A. Bremer, MD, PhD, Alice S. Baker, BA, Sally Ozonoff, PhD, Robin L. Hansen, MD, and Irva Hertz-Picciotto, PhD
http://www.pediatricsdigest.mobi/content/129/5/e1121.abstract
Allostatic Load is associated with symptoms in chronic fatigue syndrome patients. Pharmacogenomics 7, 485-494.
Goertzel, B., Pehnachin, C., Coelho, L., Maloney, E., Jones, J. and B. Gurbaxani
http://www.ncbi.nlm.nih.gov/pubmed/16610958
The selfish brain: competition for energy resources.
Peters A, Schweiger U, Pellerin L, Hubold C, Oltmanns KM, Conrad M, Schultes B, Born J, Fehm HL.
http://www.ncbi.nlm.nih.gov/pubmed/15172762
A randomized controlled pilot trial of oral N-acetylcysteine in children with autism.
Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R.
http://www.ncbi.nlm.nih.gov/pubmed/22342106
Oral Treatment with γ-Aminobutyric Acid Improves Glucose Tolerance and Insulin Sensitivity by Inhibiting Inflammation in High Fat Diet-Fed Mice
Jide Tian, Hoa N. Dang, Jing Yong, Wing-Sheung Chui, Matthew P. G. Dizon, Catherine K. Y. Yaw, Daniel L. Kaufman
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025338
Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism
Stéphane J. Baudouin, Julien Gaudias, Stefan Gerharz, Laetitia Hatstatt, Kuikui Zhou, Pradeep Punnakkal, Kenji F. Tanaka3, Will Spooren, Rene Hen, Chris I. De Zeeuw, Kaspar Vogt, Peter Scheiffele
http://www.sciencemag.org/content/early/2012/09/12/science.1224159
Oxidative stress, glutamate, and neurodegenerative disorders.
Coyle JT, Puttfarcken P.
http://www.ncbi.nlm.nih.gov/pubmed/7901908
A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics
D Nguyen, M V Alavi, K-Y Kim, T Kang, R T Scott, Y H Noh, J D Lindsey, B Wissinger, M H Ellisman, R N Weinreb, G A Perkins and W-K Ju
http://www.nature.com/cddis/journal/v2/n12/full/cddis2011117a.html
The neurobiological properties of Tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
Bruce S. McEwen, Sumantra Chattarji, David M. Diamond, Thérèse M. Jay, Lawrence P. Reagan, Per Svenningsson, and Eberhard Fuchs
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902200/
GLYX-13, an NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Robert L Balster, J David Leander, Patric K Stanton, Amanda L Gross, Roger A Kroes and Joseph R Moskal
http://www.nature.com/npp/journal/vaop/naam/abs/npp2012246a.html
On the potential role of glutamate transport in mental fatigue
Lars Rönnbäck and Elisabeth Hansson
http://www.jneuroinflammation.com/content/1/1/22
Our explanation for the origin of mental fatigue at a cellular level
University of Gothenburg
Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome
Alicia K Smith, Hong Fang, Toni Whistler, Elizabeth R Unger, Mangalathu S Rajeevan
http://www.ncbi.nlm.nih.gov/pubmed/21912186
Huntington’s disease: the case for genetic modifiers
James F Gusella and Marcy E MacDonald
http://genomemedicine.com/content/1/8/80
Reelin and Autism. Prenatal Viral Infection and Development of Brain Disorder: Implications for Genesis of Schizophrenia and Autism
S. Hossein Fatemi, M.D., Ph.D
http://www.utoledo.edu/med/depts/psych/pdf/Viral_Toledo_2011.pdf
An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Leonard A. Jason, Matthew Sorenson, Nicole Porter, and Natalie Belkairous
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166239/
Wikipedia – Kindling (sedative-hypnotic withdrawal)
http://en.wikipedia.org/wiki/Kindling_(sedative-hypnotic_withdrawal)
The independent (UK) – Anti-anxiety drug benzodiazepine ‘raises elderly dementia risk’
Sensory and cognitive event-related potentials in myalgic encephalomyelitis
Deepak Prasher, Alison Smith, Leslie Findley
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1014138/
The little pill that could cure alcoholism
The Observer, May 2010
James Medd
http://www.guardian.co.uk/society/2010/may/09/alcoholism-health-doctor-addiction-drug
Small fiber neuropathy: A burning problem
JINNY TAVEE, MD, LAN ZHOU, MD, PhD
http://www.ccjm.org/content/76/5/297.full
Many Fibromyalgia Patients Have Small-Fiber Polyneuropathy
Anne Louise Oaklander, MD, PhD,
Reported in Medscape and the press
hughes-syndrome.healthunlocked.com/…/Many–Fibromyalgia–Patien…
Chemotherapy-induced peripheral neuropathy: prevention and treatment.
Pachman DR, Barton DL, Watson JC, Loprinzi CL.
http://www.ncbi.nlm.nih.gov/pubmed/21814197
Glutamate Carboxypeptidase Inhibition Reduces the Severity of Chemotherapy-Induced Peripheral Neurotoxicity in Rat Valentina A. Carozzi, Alessia Chiorazzi, Annalisa Canta, Rena G. Lapidus, Barbara S. Slusher, Krystyna M. Wozniak and Guido Cavaletti nhttp://link.springer.com/article/10.1007/s12640-009-9114-1/fulltext.html#Sec32
Glutamate in CNS neurodegeneration and cognition and its regulation by GCPII inhibition. Rahn KA, Slusher BS, Kaplin AI. http://www.ncbi.nlm.nih.gov/pubmed/22304712
Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic Modulation via Fumaric Acid Esters. De-Hyung Lee, Ralf Gold and Ralf A. Linker http://www.mdpi.com/1422-0067/13/9/11783
Effects of dimethyl fumarate on neuroprotection and immunomodulation. Philipp Albrecht, Imane Bouchachia, Norbert Goebels, Nadine Henke, Harald H Hofstetter, Andrea Issberner, Zsuzsa Kovacs, Jan Lewerenz, Dmitrij Lisak, Pamela Maher, Anne-Kathrin Mausberg, Kim Quasthoff, Corinna Zimmermann, Hans-Peter Hartung, and Axel Methnerhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419128/
Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study. Øystein Fluge, Ove Bruland, Kristin Risa, Anette Storstein, Einar K. Kristoffersen, Dipak Sapkota, Halvor Næss, Olav Dahl, Harald Nyland, Olav Mellahttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026358
Altered functional B-cell subset populations in patients with chronic fatigue syndrome compared to Healthy Controls A.S. Bradley, B. Ford and A.S. Bansal http://onlinelibrary.wiley.com/doi/10.1111/cei.12043/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+15+December+from+10%3A00-12%3A00+GMT+%2805%3A00-07%3A00+EST%29+for+essential+maintenance
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN, Leong HX, Glassford A, Caimol M, Kenkel JA, Tedder TF, McLaughlin T, Miklos DB, Dosch HM, Engleman EG. http://www.ncbi.nlm.nih.gov/pubmed/21499269
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Prof Josep Dalmau, MD, Eric Lancaster, MD, Eugenia Martinez-Hernandez, MD, Prof Myrna R Rosenfeld, MD, and Prof Rita Balice-Gordon, PhD http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158385/
GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders.Boronat A, Sabater L, Saiz A, Dalmau J, Graus F. http://www.ncbi.nlm.nih.gov/pubmed/21357831
Possible role for glutamic acid decarboxylase in fibromyalgia symptoms: a conceptual model for chronic pain. Fitzgerald CT, Carter LP. http://www.ncbi.nlm.nih.gov/pubmed/21684692
Rituximab used successfully in the treatment of anti-NMDA receptor encephalitis.Ikeguchi R, Shibuya K, Akiyama S, Hino S, Kubo H, Takeda T, Shibata N, Yamamoto K. http://www.ncbi.nlm.nih.gov/pubmed/22728495
Does methylphenidate reduce the symptoms of chronic fatigue syndrome? Blockmans D, Persoons P, Van Houdenhove B, Bobbaers H.http://www.ncbi.nlm.nih.gov/pubmed/16443425?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum.Horvitz JC. http://www.ncbi.nlm.nih.gov/pubmed/12445716
Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. Tunbridge EM, Harrison PJ. http://www.ncbi.nlm.nih.gov/pubmed/21769726
Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Harrison PJ, Tunbridge EM. http://www.ncbi.nlm.nih.gov/pubmed/17805313
Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT.Marenco S, Savostyanova AA, van der Veen JW, Geramita M, Stern A, Barnett AS, Kolachana B, Radulescu E, Zhang F, Callicott JH, Straub RE, Shen J, Weinberger DR.http://www.ncbi.nlm.nih.gov/pubmed/20357758
Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural TissuesMarcela Julio-Pieper, Peter J. Flor, Timothy G. Dinan and John F. Cryan http://pharmrev.aspetjournals.org/content/63/1/35.full
The Immune System and Neuroinflammation: Cytokines, NK Cells and Bugs – Part V of the Neuroinflammatory Series in ME/CFS
Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Ekua W Brenu, Mieke L van Driel, Don R Staines, Kevin J Ashton, Sandra B Ramos, James Keane, Nancy G Klimas and Sonya M Marshall-Gradisnik http://www.translational-medicine.com/content/9/1/81
Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data.
Maes M, Twisk FN, Johnson http://www.ncbi.nlm.nih.gov/pubmed/22521895 Chronic fatigue syndrome, the immune system and viral infection
A.S. Bansal, A.S. Bradley, K.N. Bishop, S. Kiani-Alikhan, B. Ford http://www.ncbi.nlm.nih.gov/pubmed/21756995 Association of peripheral inflammatory markers with chronic fatigue in a population-based sample Charles L. Raison, Jin-Mann S. Lin, William C. Reeves http://www.sciencedirect.com/science/article/pii/S0889159108004261
Medscape – Primary Biliary Cirrhosis Clinical Presentation. Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: Julian Katz, MD. http://emedicine.medscape.com/article/171117-clinical
TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis. Joanna Raszeja-Wyszomirska, Ewa Wunsch, Agnieszka Kempinska-Podhorodecka, Daniel S. Smyk, Dimitrios P. Bogdanos, Malgorzata Milkiewicz, and Piotr Milkiewicz http://www.hindawi.com/journals/cdi/2013/510547/
Natural Killer Cell Function, an Important Target for Infection and Tumor Protection, Is Impaired in Type 2 Diabetes. Jeannig Berrou, Sophie Fougeray, Marion Venot, Victor Chardiny, Jean-François Gautier, Nicolas Dulphy, Antoine Toubert, Marie-Noëlle Peraldi. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062418
Oxygen radical-induced natural killer cell dysfunction: role of myeloperoxidase and regulation by serotonin. Åsa Betten, Claes Dahlgren, Ulf-Henrik Mellqvist, Svante Hermodsson and Kristoffer Hellstrand http://www.jleukbio.org/content/75/6/1111.full
Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity. Xiangling Wang, Astrid Ottosson, Chunyan Ji, Xiaoli Feng, Magnus Nordenskjöld, Jan-Inge Henter, Bengt Fadeel, and Chengyun Zheng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663610/
Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. Ekua W Brenu, Mieke L van Driel, Donald R Staines, Kevin J Ashton, Sharni L Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra B Ramos and Sonya M Marshall-Gradisnik. http://www.translational-medicine.com/content/10/1/88
CD56bright Human NK Cells Differentiate into CD56dim Cells: Role of Contact with Peripheral Fibroblasts. Antoni Chan, Deng-Li Hong, Ann Atzberger, Simon Kollnberger, Andrew D. Filer, Christopher D. Buckley, Andrew McMichael, Tariq Enver and Paul Bownesshttp://www.jimmunol.org/content/179/1/89.full
CD56bright natural killer (NK) cells: an important NK cell subset. Poli A, Michel T, Thérésine M, Andrès E, Hentges F, Zimmer J. http://www.ncbi.nlm.nih.gov/pubmed/19278419
Prolonged Illness after Infectious Mononucleosis Is Associated with Altered Immunity but Not with Increased Viral Load. Barbara Cameron, Mandvi Bharadwaj, Jacqueline Burrows, Chrysa Fazou, Denis Wakefield, Ian Hickie, Rosemary Ffrench, Rajiv Khanna and Andrew Lloyd http://jid.oxfordjournals.org/content/193/5/664.long
Chronic fatigue syndrome following infections in adolescents. Ben Z Katz, Leonard A Jason http://www.researchgate.net/publication/233976132_Chronic_fatigue_syndrome_following_infections_in_adolescents
Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death. Chun-Jung Chen, Yen-Chuan OU, Cheng-Yi Chang, Hung-Chuan Pan, Su-Lan Liao, Shih-Yun Chen, Shue-Ling Raung, Ching-Yi Lai http://onlinelibrary.wiley.com/doi/10.1002/glia.22282/abstract
Catechol-O-Methyltransferase val158met Genotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex. Michael N. Smolka, Gunter Schumann, Jana Wrase, Sabine M. Grüsser, Herta Flor, Karl Mann, Dieter F. Braus, David Goldman, Christian Büchel, and Andreas Heinz. http://www.jneurosci.org/content/25/4/836.short
SNPedia rs4680 (Val158Met). http://snpedia.com/index.php/Rs4680
GENE REVEALS SEX DIFFERENCES IN THE BRAIN. British Association for Psychopharmocology – Press release. Dr Elizabeth Tunbridge. http://www.bap.org.uk/pdfs/Tunbridge_-_Press_release_-_GENE_REVEALS_SEX_DIFFERENCES_IN_THE_BRAIN-_July_2010.pdf
Etiology of chronic fatigue syndrome: testing popular hypotheses using a national birth cohort study. Harvey SB, Wadsworth M, Wessely S, Hotopf M. http://www.ncbi.nlm.nih.gov/pubmed/18378866
Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosisBibiana Bielekova, Marta Catalfamo, Susan Reichert-Scrivner, Amy Packer, Magdalena Cerna, Thomas A. Waldmann, Henry McFarland, Pierre A. Henkart, and Roland Martin. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458677/
Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity. Balada E, Ordi-Ros J, Vilardell-Tarrés M.http://www.ncbi.nlm.nih.gov/pubmed/19714703
Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis. Magdalena Janina Laska, Tomasz Brudek, Kari Konstantin Nissen, Tove Christensen, Møller-Larsen Anné, Thor Petersen and Bjørn Andersen Nexø http://jvi.asm.org/content/early/2012/01/18/JVI.06723-11
Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease. H B Urnovitz and W H Murphy http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172883/
Ancient Retrovirus May Contribute to Chronic Fatigue Syndrome, Multiple Sclerosis and Autoimmunity Reuters http://www.reuters.com/article/2008/06/23/idUS127935+23-Jun-2008+MW20080623
Human Endogenous Retrovirus-K18 Superantigen Expression and Human Herpesvirus-6 and Human Herpesvirus-7 Viral Loads in Chronic Fatigue Patients. Brendan Oakes, Matthias Hoagland-Henefield, Anthony L. Komaroff, Jessica L. Erickson, and Brigitte T. Huber http://cid.oxfordjournals.org/content/early/2013/02/13/cid.cit086.abstract
Plasmacytoid Dendritic Cells in the Duodenum of Individuals Diagnosed with Myalgic Encephalomyelitis Are Uniquely Immunoreactive to Antibodies to Human Endogenous Retroviral Proteins. KENNY L. DE MEIRLEIR, SVETLANA F. KHAIBOULLINA1, MARC FRÉMONT, JAN HULSTAERT, ALBERT A. RIZVANOV, ANDRÁS PALOTÁS and VINCENT C. LOMBARDI http://www.wpinstitute.org/news/docs/invivo27_177-188_2013.pdf
Influence of Antipsychotic Drugs on Human Endogenous Retrovirus (HERV) Transcription in Brain Cells. Olivia Diem, Marisa Schäffner, Wolfgang Seifarth, and Christine Leib-Mösch. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256206/
Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder. H Perron, N Hamdani, R Faucard, M Lajnef, S Jamain, C Daban-Huard, S Sarrazin, E LeGuen, J Houenou, M Delavest, H Moins-Teiserenc, D Bengoufa, R Yolken, A Madeira, M Garcia-Montojo, N Gehin, I Burgelin, G Ollagnier, C Bernard, A Dumaine, A Henrion, A Gombert, K Le Dudal, D Charron, R Krishnamoorthy, R Tamouza and M Leboyer. http://www.nature.com/tp/journal/v2/n12/full/tp2012125a.html
Polymorphisms in human endogenous retrovirus K-18 and risk of type 2 diabetes in individuals with schizophrenia. Dickerson F, Rubalcaba E, Viscidi R, Yang S, Stallings C, Sullens A, Origoni A, Leister F, Yolken R.. http://www.ncbi.nlm.nih.gov/pubmed/18617371
No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. Nyegaard M, Demontis D, Thestrup BB, Hedemand A, Sørensen KM, Hansen T, Werge T, Hougaard DM, Yolken RH, Mortensen PB, Mors O, Børglum AD. http://www.ncbi.nlm.nih.gov/pubmed/22495247
N-Linked Glycosylation and Sequence Changes in a Critical Negative Control Region of the ASCT1 and ASCT2 Neutral Amino Acid Transporters Determine Their Retroviral Receptor Functions. Mariana Marin, Dimitri Lavillette, Sean M. Kelly, and David Kabat http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149750/
GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia. Hedi Hegyi. http://www.biology-direct.com/content/8/1/5
Raltegravir (Isentress) Pilot Study in Relapsing Multiple Sclerosis (INSPIRE)/ Gavin Giovannoni, Queen Mary University of London http://clinicaltrials.gov/show/NCT01767701
Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder. Beatrice A. Golomb. http://precedings.nature.com/documents/6847/version/1
