No Useful Purpose
Allodynia is a particularly nasty and mysterious problem. One of the first things to get about allodynia is that it serves no useful purpose. Other types of pain serve to protect an injured area but there’s nothing protective about a condition that causes pain at the touch of clothing.
With about twenty percent of the population suffering from a chronically painful condition, pain has become a huge problem in our society. With the population aging and rates of diabetes – a major cause of allodynia – skyrocketing, pain will sure become an even bigger problem in the future.
In this blog we take a look at a recent overview of allodynia and see where we’re at with this perplexing condition.
Mechanical allodynia. Lolignier S, Eijkelkamp N, Wood JN. Pflugers Arch. 2015 Jan;467(1):133-9. doi: 10.1007/s00424-014-1532-0. Epub 2014 May 22.
Unfortunately it appears that allodynia, like other types of pain, appears to be caused by different factors in different people. Some sensory neurons may be involved in some people, and other sensory neurons in other people. Sympathetic nervous system neurons, for instance, are clearly involved in triggering allodynia in some people but not in others.
Some people with bone cancer pain have a type of allodynia which does not appear to involve any of the normal pain mechanisms understood to produce pain. The cause of their allodynia is a complete mystery.
Do You Have Allodynia?
At least four different kinds of allodynia exist:
- Tactile mechanical allodynia – triggered by touch
- Static mechanical allodynia – triggered by light pressure
- Dynamic mechanical allodynia – triggered by brushing the skin
- Thermal allodynia – triggered by cold or hot stimuli
A simple touch can be excruciatingly painful in allodynia
Severe allodynia is painfully obvious to anyone who has it but if you have a more moderate case you might be unaware that it’s present. You can check for allodynia by applying a cotton pad or cold or warm compress to your skin. If you feel pain or tenderness, tingling or pins and needles or a burning sensation you may have allodynia.
A wide variety of conditions including neuropathies (from diabetes, B-vitamin deficiencies), migraine, fibromyalgia, demyelinating diseases and midbrain problems are associated with allodynia.
While much remains to be understood, and allodynia is still not getting the resources it should be, significant progress is being made in understanding its cause.
The Body
Any understanding of allodynia should probably begin at ion channels found in the sensory neurons in the skin that respond to touch. Since the slightest touch is able to trigger allodynia in susceptible people researchers believe that stretch receptors which respond to very slight stretching of the cells of the skin are involved.
The finding that a toxin called conotoxin NMB-1 that reduces electrical currents is able to reduce pain sensitivity without interfering with the ability to ascertain touch, indicates that electrical currents are involved. However, it’s not yet clear yet which ion channels this current is associated with.
“TRPA1 appears to dynamically respond to an amazingly wide range of diverse stimuli that include apparently unrelated modalities such as mechanical, chemical and thermal stimuli that activate somatosensory neurons.” Garrison – the Dynamic TRPAI Channel
The ion channels that register “stretch” are clearly affected in allodynia
The TRP1A channel is one possibility. This ion channel, which is found in many cell types, translates stimulation from environmental irritants, heat, cold and stretch into nervous system activity. It is heavily involved, for instance, in producing pain signals in response to bacterial infections. Removing the TRP1A ion channel from mice increases their tolerance of noxious stimuli dramatically. This channel also, interestingly enough, can affect blood vessel functioning.
A recent review of the TRPA1 channel unequivocally stated it’s involved in fibromyalgia and other persistent pain states. It’s not clear that TRP1A, however, is telling the sensory nerves to go banana’s every time the cells on the skin experience a slight stretch. It’s involved but it doesn’t appear to be the answer.
The Kv1.1 potassium channel, on the other hand, might be. It both responds to stretch and appears to put a damper on the type of electrical current involved in allodynia. (Mice bred without these protective potassium channels invariably experience allodynia.)
Simply knocking out the ion channels could lead to an inability to detect sensation and result in further injury. A better approach might be to stop the pain at a different level. That brings us to immune system manipulation.
Immune Factors
A great deal of research has been focused on understanding how immune factors contribute to pain sensitization at the level of the sensory neurons. Little is knownm unfortunately, how they contribute to allodynia.
Researchers do know that injecting an intracellular messenger called cAMP that is often associated with inflammation can cause profound allodynia in laboratory animals. They also know that inducing allodynia in mice that are deficient in adenylate cyclase – an enzyme that produces cAMP – has proven to be difficult. cAMP, therefore, is definitely involved in allodynia.
The cAMP situation is confused, though, by the finding that a important byproduct of cAMP activation called PKA which plays a major role in producing inflammation triggered pain is apparently not involved in allodynia.
An unusual pain producing pathway is associated with allodynia
That was a surprise. Further studies, however, found evidence of an alternate cAMP activated pathway called epac in allodynia which is entirely distinct from the pain pathways associated with inflammation.
Further studies indicated that activation of the epac pathway sensitizes the sensory neurons involved in sensing touch. Then research indicated that this new pathway is also associated with the production of proteins that regulate sensory neuron activity.
Researchers ability to reduce allodynia in mice by knocking down the levels of these proteins suggests that the epac pathway may be the real deal. An epac antagonist has recently been developed to fight cancer.
Epac does its work not in the skin but at the dorsal root ganglia: a gathering place for pain and other signals that’s found just outside the spine. Manipulating these channels could hold the key to reducing allodynia.
Central Sensitivity
Sensory neurons and the immune system are clearly implicated in allodynia. Studies suggest the dorsal root ganglia found just outside of the spinal cord are effected as well, and so is the central nervous system.
Like other aberrant pain sensitization states allodynia may present something of a perfect storm which affects every pain processing aspect in the body and the brain in some way.
It’s clear that central nervous system sensitization is present in allodynia. It appears the microglia are involved and that raises the spectre of an dysregulated neuro-immune interface.
Calling microglial activation a possible “spin-off” from normal wound healing in the periphery, the authors presented a scenario in which a barrage of stimuli from the body sensitizes neurons in the dorsal horn of the spinal cord. That opens up ion channels called TRPVI which promptly shut down inhibitory pain pathways associated with GABA, providing the crucial step of increasing the level and intensity of pain signals sent to the thalamus. The stage is set for an enduring case of central sensitization.
Stopping Allodynia
Four strategies for stopping allodynia were put forth:
- Blocking mediators such as BDNF, cytokines and nerve growth factor that sensitize the neurons in both the central nervous system and periphery.
- Blocking the activity of the ion channels that tell the nerves the cells are being touched (stretched). Thus far one channel – Piezo2- is a potential candidate but more surely play a role.
- Trying to turn down the electrical activity in the pain producing channels found in the sensory nerves. Some success with this is being found in animal studies.
- Dismantling the aberrant circuitry that has been linked to allodynia.
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I’m surprised that Complex Regional Pain Syndrome 1 (formally known as Reflex Sympathetic Dystrophy) isn’t mentioned here in relation to allodynia. I have CRPS, FMS, and CFS; although there is some who think the FMS& CFS symptoms are actually a progression of crps. Certain my my crps came first and the severe allodynia is the most acute pain I have ever felt in my life. I didn’t know that allodynia is associated with the other conditions. Interesting how they all share so many of the same symptoms.
I agree it should have been in there and I don’t know why it wasn’t mentioned in the sources I checked out.
Given the high prevalence of diabetes and it’s association with neuropathic pain and allodynia – hopefully allodynia will get more finding in the future.
Sandra , mine all started with RSD also. I also have FMS & CFS. And now I know the name of this other crazy affliction I have!! Allodynia ! How are You coping on s daily basis??
It’s a theoretical relief to know that at least work on this continues. From my own observations of a very severe form of this condition over the last 3 + years I have to say the involvement of the immune system is without doubt. I sincerely hope that better medication than pregabalin can be found to ameliorate this state of affairs but being an animal lover also hate the process which inevitably seems to require other living things being tormented by it.
Lilpink, I concur re your comment of “…being an animal lover also hate the process which inevitably seems to require other living things being tormented by it.”
As someone whose been involved for many a year in animal rescue, my mind can’t help but recoil in horror whenever I read stuff like “…injecting an intracellular messenger called cAMP that is often associated with inflammation can cause profound allodynia in laboratory animals.” To know that animals are purposely made to suffer in a manner described as ‘profound’ (read intense) strikes at me to my very core:-(((( I am not naive enough that I do not realize that animals die everyday so that humans can live but I have never understand why they must be made to endure horrible suffering for that end to be accomplished. Surely with all our modern science & technology there is a far better way?!
I sincerely wish there was. Animals are used extensively in medical research that I don’t know that there is..I don’t think there’s any good answer to this. I agree that it is an appalling situation..
Would another version of allodynia be a mounting pain response over minutes, an hour or more, to the touch of cloth, jewelry, elastic or the like, which would never bother a normal person? In other words, the pain is not instantaneous but keeps increasing over minutes and hours to either pressure, tightness, slightly rough cloth or even synthetics like fleece and acrylic. This is one of the kinds of pain I have, but I have never had immediate pain to light touch or pressure. I wonder if the same process is involved or not? It could be, unfortunately, that allodynia is slowly increasing in me so that this immediate response may one day be the case. I suspect this may possibly be the case because the time I can last with these negative stimulators is going down.
that is how mine began approximately 30 years ago. now even someone touching me sets off a major, wide-spread pain response. if i am having a fibromyalgia flare, the touch of my clothes sets off off a major, wide-spread pain response. i do have degenerative spine disease as well so i find the connection to dorsal root ganglia interesting.
I’m in the same situation.
Although the strangest part is that I may experience some pain from something like my hair touching my neck for 2 weeks in a row and then stop feeling that for some time… That occurs in others areas too.
When it first started it was just from heavy clothes, now I feel pain from light clothes too.
But even though that’s one of the most scary symptoms and also one of the most anoying I feel that it is also the less “permanent” as it changes so much, comes and goes. And when I experienced the best relief some time ago it was the symptom wich got the best results.
One thing common to many people with fibro, and certainly used to be the case with me, was the weight of bedclothes on the feet was intolerable if lying on one’s back, but if lying on one’s side, the pressure of the weight of one leg against the other at any point was also intolerable. Same with one arm if it rested against the body anywhere.
These intolerances have subsided with me as my overall condition has been improved by all my coping strategies, especially “pacing”.
That’s great news Phil. I notice that my chemical sensitivities – which are just another kind of hypersensitivity reaction – improve when my energy levels improve.
Pacing in all things – pacing physically, emotionally, mentally – keeping the activity of one’s systems down – so they can rejuvenate, is very important I think.
Phil:
I have the sort of pain you are referring to. It is the pressure for me and it gets worse as the day goes on. For instance at this moment (9:10pm), my feet are on fire but also my hands and feet hurt from any time of pressure, ie laying on top of each other or brushing my teeth (squeezing the toothbrush) or driving for example). It just takes the smallest thing sometimes. In fact, aside from Tramadol that I take, which only helps a little bit for me, I have a hot tub which I use almost every night, even in NC winters (mild for most folks). I also like to pet my dog, which may sound strange but it is like that application changes the current message of PAIN PAIN PAIN to soft soft soft. I call it a way to psych my mind/ body out by touching something that isn’t pressure related, it’s a different sensation. It has to be something soft like silk for example. These are just very small ways that I cope a few minutes without pain. The pressure of the covers under the bed hurts my feet and heels, I usually stick them out of the covers. Cool air flowing over them feels good. It is very hard to live like this. I’m in tears almost every night, my husband feels so helpless and saddened by this. There isn’t much he can do but support me and we try to find new ways to cope or improve existing methods, ie hot tub, etc. I’m a changed person since being diagnosed with small fiber sensory neuropathy and fibromyalgia! I also have restless legs syndrome and arthritis! What are your experiences?
It appears to me that you’re describing a form of delayed allodynia…
THANK YOU CORT!!! I now have a name for one of my pains! The doctors where I go to are young trainees and generally from third world countries so getting help is difficult. Changing to another practise is near impossible at present. It is soo good to have a name for it:)
🙂
Cort – is delayed allodynia a medical term? I’ve never heard it before, and though I have the problems described by Jazel and Phil, it is nothing like the diagnosed allodynia I had from crps. Not even close.
Hi Christine – when I’m in a bad flare then a shower is painful for me. For that reason and others, like balance etc, I almost always bathe. But I too get pain relief from the sun if it is close to 30 degrees or higher. You’re the first person I’ve heard who shares that relief. Too bad I live in a very cold, northern climate!!! I couldn’t live without a tub and am so sorry you can’t get that simple relief.
I also have experience relating to heat and body heat regulation and management.
At the peak of my fibro problems, which I now realise were highly related to failure to understand pacing, and constantly overdoing my attempts to retain fitness, I suffered from body heat regulation issues. My exercise program that I tried to keep up every day would leave me flushed and sweating for hours afterwards. It was socially embarrassing and I had to avoid exercise altogether for hours prior to important socialising occasions. If I exercised before work, I would not stop sweating until about lunchtime and my clothes would be saturated with sweat in some spots (and I would change into clean clothes once I knew I had stopped sweating). If I exercised after work, I would still be flushed and sweating when it was time to go to bed.
I also had major intolerance to heat, I could not stand hot weather. Hot baths would also leave me so sweaty afterwards that I might as well not have had one.
But I never found showering painful, or detested water like some fibro victims do. I usually found it a relief when too hot. It was not possible though, to cool myself down after exercise to the point where I would not return to hot, flushed and sweaty again afterwards if long enough time had not elapsed. And this heat never felt beneficial – I realise now it was associated with “post over-exertion malaise”.
But since Cort informed his readers about pacing and I have been trying it (along with lots of other things) I have lost those frustrating long overheated episodes, love direct hot sunshine (soothes muscles), can tolerate hot weather, and can cool myself down quickly with cold water (shower or swimming pool). I always aim to do this after my paced exercise, and also after a hot spa, which I have made part of my strategy now that it does not need to leave me overheated like it used to.
I think heat is beneficial as a treatment, but being overheated and staying that way for hours is not beneficial. Paced exercise warms me up nicely, and after that, and after a spa, and on very hot days, I make a point of cooling myself down again as soon as possible by getting into the swimming pool (near where I live and also right where I use a fitness centre for a workout program). Within minutes I am cooled down again, plus I try and quickly get into fresh or airconditioned air again; indoor swimming pool air is warm and moist and brings back sweating if I remain in it too long. An outdoor swimming pool (there is one a bit further away and only open for half the year), is something I find more beneficial. Being in the fresh air and sunshine as well as in the water.
I don’t know if this is all guaranteed to help others, it is just my experience so far. I am really positive with progress. I am recovering the ability to do things like squatting down on my haunches, that I have been unable to do for years. And the rapid onset of breathlessness and increased heart rate when putting myself in certain positions (like squatting, or doing quad stretches, or bending forwards at the waist) is also diminishing. I have hypothesised for a while that this is related to myofascial blood flows being constricted when going into these positions, so maybe recovery from the worst of fibro is restoring the myofascia’s flexibility?
Besides the pacing of exercise, I credit switching to a low-stress livelihood years ago that I have finally become financially secure in (built up my client base), and a couple of excellent massage therapists, especially the Qi Gong one. I am so impressed with him – he is a Chinese migrant and has language difficulties – that I have been instrumental in getting him into a large shared medical premises with a number of doctors and other practitioners including other Chinese speakers who can help him forwards in his career. They have vetted him and been just as impressed with him as I am. He clearly understands fibromyalgia (from training and experience in China) and has an amazing massage protocol for it. He is sort of gradually, treatment by treatment, chasing the pain and tension back into smaller and smaller residual locations. There are sizeable areas of my body that are now able to tolerate a full-on deep tissue massage, once quite impossible. The usual pain nodes are still there and very touchy but he has gradually been working carefully onto and over them and this is becoming more bearable.
He may end up having his knowledge incorporated into a mainstream medical protocol development program for fibro treatment here. Obviously there are things known in Chinese medicine and massage techniques that the western mainstream needs to tap into.
Hi there Phil Hayward!
I must thank you for the information you have shared here! You have listed almost exactly the problems I face with persperation and intolerance of heat -your discriptions make me feel ‘yayy!’ I am not imagining any of it. It is real for someone other than myself.
I have had the problems since I was about 37…. and the embarassment it has caused in my life all these years – is indescribable! (I am now 60yrs of age). There are times when for 3 days… (day and night) in the recent heatwave we have suffered in the country I live in, have kept my head wet permanently… I feel untidy and horrid!…. Washing and gelling often, is the only way I can cope with it…. Curling it… is a waste of time… because, by the time it should have curled…it is all wet again!…
I am most sincerely grateful for your share…it makes me feel normal under the circumstances… (I was diagnosed with ME innitially then with CFS and more recently with Gerds.. I have had 2 heart-attacks followed by a double by-pass… both incidents which I survived extremely well…but which have left me very tired all the time!
Thank you again for your ‘share’ Liz Wallis
I get a similar pain when I eat too much oxalate. Anyone else?
Oh yeah. My Rhume diagnosed oxalates problem when I walked in the door. Oxalates can settle in joints and mimic carpel tunnel and tarsel tunnel. After about 6 months detoxing with something called intense cleanse I found the pain mostly gone. Also try to stay away from foods high in oxalates.
Thanks Cort for this article on allodynia as it is very timely for me.
I have trawled the internet for seam free clothing and as soon as I buy clothing, I pick out every stitch holding the label on if it is likely to come into direct contact with my body. I don’t (yet!) have sensitivity to the weight of clothing. In recent years, I have been on both pregabalin and Duloxetine and don’t know if that is why, but I have become slightly less sensitive. However, I still only get dressed to go out and as soon as I am back home, I change back into my seam free night dresses and baggy drawstring trousers with the drawstring only very losely ‘tied’.
What I am identifying as allodynia at the moment is the ‘discomfort’ rather than pain I suffer from the feeling of water on my skin in the shower. I have to have a friend or carer present to even get in the shower and even then I shower only twice a week which is not how it used to be! For some reason the heat of summer reduces this discomfort and I might jump in the hower twice a day – so long as I don’t turn it on my head. I have become so phobic of showers that i have been funded for a carer for two showers a week.
When I get in a bath (tub), I shiver regardless of the temperature of the water, until my whole body is emersed but then it is comfortable. It would be great to change my shower for a bath but I live in social housing (in the UK) and with the austerity that our govt has enforced, my landlord does not have the funds to do this work.
If more were known about allodynia, I might be able to do this.
Roll on the day when they figure it out!
Has anybody else had this experience with a shower or know of anybody who has?
christine.. Forgot to leave My name on my response to You..
I have found that wearing (next-to-my-skin) clothing inside out helps, especially night clothes & t shirts. Also I have bought a silk filled duvet which is warm enough without being heavy -a great blessing & well worth buying…
A word about pregabalin, I was told by a GP today that great care has to be taken if coming off this drug, has to be really slowly or withdrawal symptoms can be horrendous -I didn’t know this so thought others might not either.
I have not seen as yet one of my problems with FM which is an extreme electricsl problem as I mess up credit card stations and one time I touched my husband while he was on the computer and it turned off. Any one else have similur problems?
Hello Cort and everyone,
after many years having acute, chronic pain in spine and joints and now muscles, today I was diagnosed with allodynia.
had never heard of it before today but here we are. knew i had fibro but did not know about allodynia as there appears to be little info on it.
rheum was top man in his field. i went private to circumvent seeing another in a long line of NHS supplied juniors, afraid to diagnose anything that may conflict with a senior doctor’s diag.
i take pregab, omep, tram, and zomorph. he said that my zomorph is high – 100mg x 2 daily plus oramorph when needed but i get into massive, ridiculous, suicidally, painful mess when i do lower it.
am scared at moment as rheum said i will have this forever and only pain courses and mindfulness can really help. have been on two sticks for 2 yrs and wheelchair for anything over 50-100m. saw wheelchair people to go electric as is getting worse, am 42. will mindfulness and pain course really help, i have been on pain courses before to no avail?
such a lot tot take in
regards
matt
Yes, indeed Matt – a lot to take in. My bet is that if you really work at them mindfulness courses will help and you will learn valuable tools for other parts of your life. They are not easy to do – and they don’t remove the pain but they can help with it and importantly they can help and over time can even remove the depression and fear that a diagnosis like that can impart.
I would not stop with any one mindfulness course – there are many ways to peel an onion with regards to mindfulness.
I would keep in touch with this guy or some other pain expert. I would find someone at an academic center, if possible, who’s up on all the latest work on pain. A variety of treatments are being examined – many are in the early stages, but the variety is encouraging. Pain is being taken more and more seriously.
I would look at diet, mold and other factors to see if you can reduce something that is stressing your system. I find mitochondrial and immune enhancers, interestingly enough to be pretty good at reducing pain! A recently study suggesting that the mitochondria were behind chemotherapy induced pain shocked the heck out of the researchers.
Thank you Cort.
My Doctor referred me to The Bath Clinic to see a Guy who ( don’t know where I stand legally if I name them ? ) is from The Royal National Hospital for Rheumatic Diseases, I
Sorry Cort, last response sent early as have a bad tremor ( arms and legs )
Anyway. I was blessed in a way as I think this man may be right onto it. He’s an osteo rheum by trade. But really kind, non judgmental and he trained at Manchester,London and then Harvard Medical School. On their website, amongst other specialities, he specialises in chronic pain, fibro and helped establish the hospitals pain management service. Above all he had the courage of his conviction wi
Sounds good. Might want to check out the Pain Research Forum – they’re often looking at the latest.
Fingers again!
I shall look into the mitochondria and immune in hangers too.
Thank you Cort and kind regards
Matthew
The allodynia on the left side of my back started with shingles 12 years ago and nothing has helped. I cannot wear clothes on top so I have been reduced to being homebound and gaining 70 pounds rather than being a very active person.
I don’t have any of the other medical conditions mentioned here, but I do have problems with pressure allodynia (static mechanical allodynia), particularly over my ankle bones and other bony areas of the feet, and over tendons of the feet. I’ve previously also had dynamic mechanical allodynia over my Achilles’ tendon – the slight friction of the back of my running shoe against the skin had me thinking I was about to suffer an Achilles’ tendon tear, it was so painful while running (and I’m a long-distance runner, so this was a real problem).
I recently fractured my ankle and in addition to internal fixation, I’m in a cast. I knew I would have pressure allodynia problems with this and I’ve already had bouts – the first one, over the Achilles’ tendon just after coming round from the anaesthesia, had me weeping (and the surprised medical staff did give me effective analgesic medication). Despite requesting extra padding around the medial malleolus (inner ankle bone) and Achilles’ tendon I’ve also had several bouts associated with the cast pressing on my medial malleolus. Neither the orthopaedic consultant nor the cast technician were expecting this, but thankfully the tech LISTENED to me and not only put in the padding I asked for (not enough, evidently, but he tried) but also split the cast down the front so that when I get the pain I can pull the cast apart to take the pressure off the tender area for a bit rather than attacking the cast with a hacksaw. Just had it on my medial malleolus during this morning and on the top of my foot during the night (the pain woke me up).
So far I’ve not found a single reference to pressure-related allodynia as a complication of casts except as part of complex regional pain syndrome – which isn’t my problem, so I can only assume it’s not a common problem. Mine feels rather like a deep bone bruise – with a really noxious element to the pain, if that makes sense to anyone. Sincere sympathies to anyone who gets this in response to e.g. clothing – must be hell!
Anything with texture gives me a stinging, itchy, crawling or burning sensation. It all started immediately after I got off all psyche meds. I can’t have animals around me because one animal hair will feel like a bee sting. My own hair burns or stings my skin. Any material other than 100% polyester or satin feels like I have ants crawling on me stinging the hell out of me. I literally have to lint roll my polyester or satin clothes and bed sheets to lessen the feeling of sleeping with ants and stinging nettles. I can’t have a companion because every little thing a person carries with them (lint, dust, animal or human hair) stings or itches. To say my life has taken a nose dive is an understatement. My friends even look at me like I’m weird because I have to be so hypervigilant about making sure nothing touches me. Skin and flat surfaces don’t bother me tho. I am going through a ton of different Drs that are treating me like I’m an idiot. They have tried calling it formication, hypersensitesia I don’t even think that’s a word), and hypersensitive. I repeatedly tell them it’s allodynia.
My gosh Ramona – that sounds so miserable – good luck with it!
Thanks, I’m gonna do a complete change up of doctors again soon! A quick piece of help to those that have the same clothing problem as myself; Try lint rolling a 100% polyester dress and that should give some relief. Or lint roll satin sheets. I do the latter to give my skin a break. Also powder Calm (for humans) from GNC helped a little when taken on an empty stomach.
I have allodynia for many years and its getting worse. I have the symtoms almost everyday and in different areas of the body. Sometimes it wakes me up at night with stabbing pain.
Do you guys have any tips on how to alleviate the pain?
Today I tried putting peppermint essential oil on it and it kinda helped, as it distracted the sensation with a new one (minty). I also notice that stress, lack of sleep and the flu makes the pain worse. Let me know if you guys have any tips 🙂
Hi Cort Johnson, any updates to this 2015 post ‘re Allodynia? I have used this post to help myself & the few others I know to explain our condition for GP’s & disabilities claims. I was finally diagnosed after 15yrs. I believe my symptoms have been from birth, connected to Cerebral Palsy. My Pain Consultant agreed. Your post has been invaluable!
I feel it’s small fibre neuropathy, but so doctors listen? If Phil is reading this, which drug is helping, or anything would be helpful. Thanks.
Or anyone else that has an answer?
I feel it’s small fibre neuropathy, but do doctors listen? If Phil is reading this, which drug is helping, or anything would be helpful. Thanks.
Or anyone else that has an answer?