In the most comprehensive study of immune factors in the cerebral spinal fluid ever done in ME/CFS, Mady Hornig and Ian Lipkin reported finding dramatic differences in ME/CFS patients.
The results of the Simmaron Research Foundation /Chronic Fatigue Initiative study suggested that an extensive immune exhaustion – caused by infection or another process – had occurred in the longer duration ME/CFS patients.
The results mirrored the findings of their recent large blood cytokine study and could help explain the cognitive problems found.
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▪ Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome
Wow, this sounds like a landmark study. Great and well done!
Now, verification and treatment research please.
Indeed….
Cort,
by these comprehensive csf studies are Borrelia and nematodes with Borrelia insde of them completely ruled out by their tests?
or has this already been ruled out in previous years?
Thank you for wading thru rheems of info.
Had come across info from 2016 and thought since so many symptoms shared between MS and ME/CFS……
Re: Dr. Alan B. MacDonald findings
https://www.healthrising.org/forums/threads/is-lyme-behind-chronic-brain-disease.4364/
……this and Julia Newtons paper. Landmark and amazing papers! Hope further work follows.
Would be interesting to read the whole paper.
Which cytokines were lower?
IL10?
Do you know a Japanese researcher found issues with IL1 signalling in the early / mid 1990s in CFS?
And that he had success in treating with Sizofiran?
“Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the central nervous system, and a shift toward an allergic or T helper type-2 pattern associated with autoimmunity.”
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A predominance of a Th2-type response is consistent with pathologies, such as autoimmunity and also atopy, a genetic predisposition toward the development of hypersensitivity reactions against common environmental antigens.
It costs to see the article. Cort can you advise which cytokines were downregulated?
Cheers