Twenty billion dollars a year… That’s how much Americans in chronic pain spend on prescription pain-killers every year. Most of these are opioid drugs, but the increasing regulatory burden foisted on them and the growing realization of how ineffective and even harmful they can be means their days are numbered.
Three non-opioid drugs have been approved for fibromyalgia but studies suggest that they’ve been of limited effectiveness in reducing pain in the overall fibromyalgia population. Survey’s suggest that about thirty percent of FM patients take opioids and many consider them more effective than the FDA-approved FM drugs.
Opioid drugs are good at reducing acute pain but that relief can come at a cost if the drugs continue to be used.
Solutions to the chronic pain problem will probably come in many forms, but one of the more intriguing is more effective and safer next-generation opioids. Recently a Smithsonian article, “America’s Long-Overdue Opioid Revolution Is Finally Here“, suggested that if the opioid revolution is not quite here yet, it’s coming fast.
The Gist
- Opioid drugs have been the mainstay of pain relief for decades but are ineffective for chronic pain and come with many potential side effects.
- At least three next generation opioid drugs – each using a different approach – are under development.
- Oligocerine, which may be helpful in tamping down fibro-flares, could be approved next year.
- Another drug built off an unusual opioid drug called buprenorphine, which has been tested and found effective and side-effect free in primates, could enter human trials in two years.
- A third drug (PMZ21) built entirely from scratch using computer modeling could enter human trials in perhaps three to five years.
In the early 2000’s researchers realized that opioid receptors were more complex than they had thought. Depending on how they were activated these receptors could turn on two pathways; the “good” pathway – which turned down nerve pain activity – and the “bad” pathway which turned down pain nerve activity but also caused things like respiratory depression, addiction and constipation.
You can guess which pathway virtually all the current crop of opioid pain-killers is using. The finding sparked efforts to create forms of opioid drugs. Currently three drugs are leading the pack, but better ones may be coming as researchers better understand how the opioid receptors work.
The Early Front-Runner
Oliceridine by Trevena has gotten all the way to phase III clinical trials in humans. The Phase II clinical trial results indicated Oliceridine produced similar amounts of pain relief as morphine but with less nausea, hypoventilation (respiratory depression) and vomiting in the short term. With 90 deaths a day from opioid painkiller overdoses in the U.S., reducing respiratory depression would be a major step forward.
If the trials are successful – the results should be announced any day now – the company plans to proceed with FDA approval at the end of the year. If the drug is approved it will be the first novel pain drug approved by the FDA in ten years.
The catch is that Trevena hopes to market Oliceridine for acute, not chronic pain, and a recent mouse study may suggest why. It found that side effects do emerge in Oliceridine over time. Oligoceridine may be a step up for acute pain management but it may take a different drug to do anything for people with chronic pain.
A key for fibromyalgia and other chronic pain patients will be the ability of the next generation opioid drugs to avoid the tolerance problems that crop up when the drugs are used over time. Tolerance occurs when more of a drug is needed over time to reduce pain. A paradoxical reaction can also occur in which the drug actually increases pain sensitivity. (The first thing some FM doctors do is try to get their patients off the drugs to see if they improve.) Plus there’s the potential problem with addiction.
Dual-Purpose Drug
Researchers at the Wake Forest Baptist Medical Center are tackling opioids in a different way. Based on a rarely used opioid drug – buprenorphine – which has less addictive properties, BU08028 latches onto the opioid receptor in the same way that current opioid drugs do but it comes with a twist: it also targets opioid receptors which may block addiction. When given to primates – which share many features of the human brain – the drug proved to be highly effective at relieving pain, was long-lasting and was non-addictive. It also did not cause respiratory depression, constipation or other side effects.
Trials for this drug could start in two years.
Designer Drug
There’s the ‘tweak an existing drug’ and there’s the ‘build a new drug up from scratch’ approach. Designing a pain drug, a molecule which not only turns on the right kind of opioid receptor but only activates the right pathways, however, is no easy feat. In fact, it couldn’t have even been contemplated until the last few years.
Using computer modeling Stanford and other researcher designed a drug from the bottom up
As reported in the Stanford Medical News, Nobel Laureate and Stanford researcher Brian Kobilka laid the foundation for a new drug in 2012 by producing the first atomic level structure of the mu-opioid receptor. Stanford, UCSF and other researchers took that model and used a computer to throw over 3 million molecular compounds at it. First they winnowed the potential candidates down to 2,500 molecules and then to 23 molecules. In the end one stood out. After researchers at Friedrich Alexander University in Erlangen, Germany tweaked it so that it would bind tightly to the receptor, they had PZM21 – perhaps the first effective and safe opioid pain-killer ever developed.
In 2016 the researchers reported in Nature that PZM21 appeared to be more effective at pain relief than morphine and caused fewer side-effects – including no signs of tolerance and addiction. Further testing is needed but as of now the drug’s future is bright.
The opium poppy and the drugs obtained from it have been used for thousands of years. They’ve proven a great boon to mankind but contain a dark side marred by addiction, tolerance and other problems. About 30,000 people a year die from painkiller overdoses in the U.S. Many others can’t get relief from pain or do so at the cost of debilitating side effects.
PZM21 isn’t ready for show time yet. It will take more investigation and mouse trials for human trials to begin, but the stage may have been set.
Pain is one of the more complex sensations produced by our bodies and it’s likely there will never be a drug that works for everyone or that is completely effective. One next-generation opioid that may be more effective at tamping down fibro flares could, however, be FDA approved for acute pain relief next year. Two more that may be effective against chronic pain could enter human trials in the next two to five years. The race for a safe and effective opioid is on and the monetary stakes – hundreds of millions, even billions of dollars in sales – couldn’t be higher.
See more new developments in pain relief
https://www.google.com/url?q=https://www.healthrising.org/blog/2013/10/18/taking-sting-pain-scorpion-venom-provide-alternative-narcotic-pain-drugs/&sa=U&ved=0ahUKEwiv4dPPp4bSAhUEs1QKHa9qC4oQFggFMAA&client=internal-uds-cse&usg=AFQjCNHpwbggYfIGSNfeTZr4wyqPKAOX9w
What bothers me about pain relief, is that if the underlying problem is stickiness in the myofascia, and if that could be resolved with some form of treatment, that treatment is the real answer. It may be related to dysfunctions in the ability for hydration.
So much of the time, the medical system is misguidedly satisfied with providing relief from symptoms, and not getting at underlying causes via the right research.
I wonder if a drug that reduces pain could also reduce some of other issues that occur in FM by removing activation of the stress response system?
How about neural therapy? I’ve seen it mentioned here as helping, and it may be an alternative to opioids.
Here’s a description:
http://www.drkaslow.com/html/neural_therapy.html
I was a pain management nurse specialist for 15 years. It was when fibromyalgia and the associated chronic fatigue first began to be diagnosed. It was known by pain management specialists as the “diagnosis when you can’t find anything physically wrong”. We had awesome success addressing it as a pain issue with an associated sleep disorder. I did the interview, history, and physical. My question to the patient, although they “hurt all over”, was can you remember the first, worst pain you had. We focused on treating that pain, meds to promote deep stage 4 sleep, where your muscles actually completely relax and recover from the days work, and it was amazing the difference and success we saw with patients. Many had old injuries such as whiplash and even from playing sports as a child that speeded up the degenerative process of the spine. Once treated appropriately, usually, a physical therapy program after pain was controlled (does no good until the underlying issue is treated) and patient began to get restorative sleep, the symptoms gradually resolved. Warning, when you actually get a good night’s sleep you will feel groggy for at least 7=10 days, it is your body recovering from exhaustion, and muscles recovering. I know I have been retired for over a decade and new studies have been performed. We were a Christian facility, not only prayed each morning for God to guide our hands, decisions and actions to help our patients, but to work his miracles. Maybe it was God, but I know in my career I saw miracles with our patients. Good Luck. I was diagnosed as terminal with a rare autoimmune disease that causes many of the same symptoms, so I not only see it from a medical side but from the patient’s view. Unfortunately, there are no FDA treatments for me, but with God’s Blessing, last year became 4th documented case to live over 10 years. As a word of encouragement to all of you suffering, every day you wake up, no matter if good or bad, it is a Blessing, Make the most of each day and listen to your body. If you need to rest and sleep, do it, and pray tomorrow will be a better day. I will keep all in my prayers and encourage you to find a physician you are comfortable with and gives you hope. All are in my prayers.
Morphine type drugs are severely dangerous in CFS/EDS they are actually life threatening I almost Died from Morphine my Heart almost stopped I was given another drug to counter-act it & told never ever take it again…Morphine is a form of heroine & yes it is highly addictive…I now have huge red flags in my Medical Charts & I also feel that most drugs today contain sucrose which is a toxin but not sure about Morphine & Yes I still think (HFI) is involved in CFS/EDS as well it could be Why everyone has issues with countless medicines so if they make new drugs they should not me made with sucrose fructose-sorbitol ever
Check, maybe you have serotonin syndrome. I almost died myself. My heart stopped. It was triggered with one single pill of the minimum dose antidepressant. Even with food containing a lot of tryptophan (increases the serotonin level)I end up very sick.
I sympathize with Paula, the nurse. I was a nurse for 30+ years. Around 2000 I began having left hip pain. I continued to work until it became severe. I was treated by a pain specialist after being diagnosed with osteoarthritis and bursitis. I left my job to follow up with treatment. I began having pain in other joints and my back. I continued receiving opioid medication management for chronic pain for years. In 2019 my doctor retired. I had been his patient for 32 years. He had been prescribing my pain medications for a while. Well, I tried to get an appointment at a clinic for a follow-up. I was told that I needed to get off of my morphine before I could be seen by any of their doctors. I was 69 years old and very concerned about my medical follow up. I eventually had no choice but to see another pain specialist to have my morphine titrated down slowly until it is discontinued. During my initial evaluation, this doctor also diagnosed me with Fibromyalgia. I have had my opioid medication decreased for 7 months now. It has been difficult since the pain and withdrawal symptoms are almost unbearable. My functioning level has also been affected. My doctor has not prescribed anything to help reduce these symptoms. He keeps telling me that we will discuss it after I am off opioids completely. Well, I m not going to live in pain the rest of my life. I will be 70 this March. I was told about a drug, Buprenorphine-Naloxone. I am researching this option.
all I know is it helps; not a big dose but only .025 which is 1/2 a normal .5 dose; I also take cymbalta and baclofen daily,but when the pain doesn’t respond to those drugs or I am in a superbad flare that .025 makes me feel almost normal; and I don’t feel high or googly and I get energy; I haven’t felt the need to increase the dose and I have been on it for 2 years; and I don’t take them everyday. of course it would be great not to be on any drugs and solve this other ways; there are so many theories out there and each of us may have different reasons for our fibro and fatigue
Thanks for passing that on Gloria and congrats.
I come from the Ehlers-Danlos camp, however, many of us have fibro-like and CFS-like symptoms–and a good portion of us also use opioids for pain–which is usually both myopathic and neuropathic–chronic and acute (from the many subluxations/dislocations of our joints).
EDSers are noticing more difficulty with obtaining our opioid medication and so some of us have done quite a bit of research on comparison of risk of opioids vs. other pain med classes, accuracy of opioid related deaths and other often reported ‘facts.’ The long and short of it is that the statistics are rather sloppy–often not parsing out which deaths come from prescriptions, mixing of prescriptions with other depressive drugs, or from the use of ‘street’ drugs. The statistics lump them all together.
Surely, there is a problem in our country, but the most recent statistics show (the last two years) that opioid deaths are way down for prescribed medications (and I should add to that that only 2-5% of patients prescribed opioids for pain actually become addicts), but the real problem now is street drugs, especially heroin. They are much cheaper than prescription drugs for the addict (and sometimes the pain patient who has been denied access to medication), however, the current problem is that they are coming into the country laced with fentanyl and some other lab created super powerful opioid derivatives. Purchasers are unaware of their strength which leads to overdose.
I also want to point out that not all people become addicts with long term use of opioids for pain. It is likely that long term use will produce dependence and increased dosage, but that is not the same as addiction. Another fallacy is that they do not work for long term pain. I and many EDSers, can attest that is false. Frankly, there are hardly any studies supporting any kind of conclusion with this issue. As Cort pointed out, the drugs that are recommended for Fibro and CFS don’t work very well and come with very nasty side effect profiles–including difficulty in discontinuation and risk for abuse.
That said, we all have different genetics and will process drugs differently. We all have different risk factors as well. Personally, I think currently opioids are one of the best tools in the tool box for fighting pain–but they are not for everybody. I do hope that researchers develop something better (and it is not an outrageously expensive patented medication only available to the few), but until they do, do your homework and don’t let the current opiophobia skew your understanding of this very valuable ‘tool’ in the pain toolbox.
I agree totally with all you said Nancy. I am a long term opioid pain med user for fibro and severe knee pain. I have been on the same dose for years. The pain medication is less than $20 per month with my insurance and I am able to work a 40 hour week on my feet all day. Without it I truly believe I would have to go on disability which would be much costlier to the government. I can manage the pain and have never ever abused the pain medication nor felt the need to. It doesn’t make me high or want more it just makes the pain go away and I can function on a normal or near normal level. So far my Dr a rheumatologist has not tried to take me off the medication and has been very understanding of my need for it.
I agree with both statements. I am also a chronic user of opioids and they work quite well with me. If I was not on it, I would be bedridden. I am in the small percentage of people who become energetic on the pills. I have energy to do my daily chores though I still suffer from post exertion, once I take my meds, I’m back to mostly normal. I have had to increase my dosage which is a downside, but it’s the only drug to have worked for me so far, so why change it. Don’t fix what isn’t broke. I have a great pain management NP that understands what I’m going through. Took me a while to find one. The only problem I have is that when I have surgery, the doctors are not taking into account my usage and giving me the smallest doses of diluadid which leaves me in severe pain. Plan to file a complaint on that one.
I take opioids as well as Cymbalta which I don’t think helps with my pain (Fibromyalgia). (Severe non diabetic Neuropathy), (Severe Osteo Arthiritis), chronic myofascial pain, Severe Lymphedema feet, ankles, legs, inflammatory arthritis etc, if it were not for opioids I don’t think I could survive. They do not take all the pain away but at least brings it down to a manageable level where I can function a little and am not laying in bed crying because I am in so very much pain.
Glad you’re getting some relief Shelley..
Hi Dianne, I am a long term CFS who doesnt have pain, but when my back goes out, take vicoden.
Paradoxically, I feel energetic, focused and able to get lots done.
If I take upper based meds for CFS, I get sleepy.Can you share where your pain doc is located?
I need one that understands this.
Many Thanks !
JJ
Excellent! 100% agree with you.
Nancy, as a former pain management nurse specialist who was diagnosed as terminal 11 years ago and had to stop work, I too have many of the same symptoms for the rare autoimmune disease as with fibromyalgia. I was in pain management just as fibromyalgia began being diagnosed. it was known as the diagnosis patients received when physicians could find nothing wrong. We were, at the time one of the best multi-disciplinary pain centers in the southeast and had patients from many states.
I did the initial patient history, interview, physical, and reviewed all records. After obtaining their information and just listening to them vent their frustration, my first question to form a treatment plan was “think back to before you began hurting all over and the chronic fatigue, what was your first, worst pain that began causing, what I bet, was problems with your sleep?”
We began treating what began the snowball effect, which in many cases was an old whiplash injury that caused the degenerative process of their spine to speed up. During the 2=3 month treatment, we prescribed medication to promote stage 4 sleep, (not typical sleep medication which helps you go to sleep but never reach stage 4 sleep which is where your muscles completely relax and recover from the day’s activity. Then, after we treated the underlying problem, they were getting restful sleep, we began a physical therapy program to recover and retrain muscles to do days activity and recover with restful sleep at night. Warning! When you finally get a good night’s sleep, you will feel groggy and like you could sleep for days. It is your body telling you it needs more rest! With this disease, I have many of the same symptoms, and when I am going through a bad time, sometimes sleep for 36 hours. but, I became the 4th documented case to live past 10 years last August. I encourage all to feel
blessed each morning when you wake up, no matter if good or bad, make the most out of it.
I am a Christian, worked at a Christian facility. Each morning we had prayed for God to guide our decisions, hands, hearts and minds to make the correct decisions for our patients and for him to be a part of each decision. Most of my nurses also, like I did, prayed with our patients when asked. I feel so Blessed because I saw miracles during my career and patients and families get their lives back!
PLEASE!!! Everyone be aware, I can promise this as a nurse and as a patient, opioid medication works wonderfully on bone, joint, and muscle pain, but only one opioid, and it has approximately a 60& chance of helping with neuropathic pain. Pay attention to what pain it helps with and find help for that pain. Unfortunately, there are only the usual anticonvulsants and antidepressants for fibromyalgia but until you get the main pain and regular stage 4 sleep to address the underlying issue they are not very
effective.
Trust me, as a nurse, I am one of the worst patients!!! And get mad as *&^$ that I can’t function as I used too. But, thank God for each day, the experience preparing me for a terminal disease that has no treatment or cure, but also realize when it is something my pain medication will help with and when it is neuropathic and just have to suffer through. I hate winter, weather change, and storms which make nerve pain so much worse. Also, nicotine and caffeine are both stimulants for nerve pain. I have never smoked, but cola is my weakness and helps with nausea.
Please know, as you take pain medication regularly, tolerance develops (not addiction_and you notice it doesn’t work as well. The answer is not to increase, but bite the bullet and decrease for a while. I recently asked my physician to decrease me due to tolerance and, because I understood I needed to and why, believe it or not, but I have not noticed a difference in the pain that it helps with (bone, muscle, joint). I will likely to decrease again next month. That way, I am slowly decreasing my tolerance and as the disease continues to progress and closer to the end, I know I will be able to pass in comfort.
I know over the last 11 years I have been away from the specialty things having changed but I know we saw miracles treating Fibromyalgia. Keep faith in God, listen to your body and please realize, as a nurse who spent more time talking patients into taking pain medication than with addiction and some one who for 11 years has suffered from the same symptoms among others such as seizures, balance problems, and memory loss, it is not the answer for fibromyalgia, it is for the underlying issue. And, yes, it bugs the heck out of me that addicts and incompetent physicians have inappropriately prescribed for so many years that patients who need it, and the poor physicians having to jump through so many hoops you cannot imagine, just to prescribe for their patients. We moved to another state, and my specialists are 3 hours away because the physicians in my area will not accept palliative care (dying patient) or simply a pill mill which I refuse to be associated with and have reported.
Find a physician you are comfortable with and have the training to treat the multiple issues associated with your diagnosis and be Thankful for each day, realizing there will be bad ones you just try to relax and get through and enjoy the good days. Listen to your body and rest when needed and know you are in my prayers.
I’ve been hearing about folks taking LSD ( about 1/10 typical dose) and it’s greatly helping their depression and overall feeling of well being.
LSD as in acid? I’ve read articles about it. That and mushrooms. Wonder how a person gets something like that! Kind of surprising, but if it works, why not.
I think that eventually the treatment for ME/CFS will be through some sort of brain stimulation. Anti-virals or anti-biotics might be a second. The symptoms are far too varied to be treated by painkillers or depressants, though of course I look forward to anything that helps.
I hope that greater focus is placed on electric stimulation devices. Cort, please update on any devices which are close to getting approval for Fibro/CFS.
Little is being done in regards to the Orphan Diseases which cause debilitating Chronic Pain. Diseases such as Complex Regional Pain Syndrome impacts such a small segment of the overall population that even if a “Miracle ” drug were developed, the expense related to taking the medication would be prohibitive and therefore useless to the segment of the population whom are not billionaires.
I don’t know about that. This is not to discount the difficulties that people with rare diseases face but drugs are being developed for rare disease which should, I would think, be covered by insurance if they are FDA approved. (???) Because the FDA doesn’t require as much data for rare diseases drug studies, at least, should be less expensive
Or it’s possible that a drug developed for another disease may prove helpful.
Allen, I was a Pain Mgt. Nurse specialist for almost 15 years. Been medically retired for 11 due to being diagnosed with a rare autoimmune disease (1 in 2 million get it, terminal with 2-5 yr life expectancy) and as a nurse, had to explain to my son just what you said. There are not enough patients with the disease for drug companies to develop medication and be able to make a profit. Unfortunately, when he learned medicine was influenced mostly by profit, he decided he did not want to go into medicine.
As a pain management nurse, please do not give up hope. What you referred to as Complex Reginal Pain Syndrome (CRPS Type II_is not rare and is also know as Reflex Sympathetic Dystrophy (RSD) which best explains the disorder. It begins as a reflex to some other problem and gradually progresses. In most cases if you treat the underlying cause the limited drug therapy controls the nerve pain (Winter, storms, weather changes make it worse), and if RSD remains, Spinal Cord Stimulation was working well. Google and search, see specialists and by all means never have any major treatment such as implant without second opinion and a trial.
I have seen patients stimulator need adjustment and come in with hand with so much Edema rings had to be cut off or leg and foot with major edema and mottling and a few adjustments and literally within 15 minutes Edema, mottling and pain resolved. 15 years ago, although only used as a last resort, it was the #1 tool for controlling RSD. In fact, at the time, there was only 1 company that produced what most considered the best implants. I was certified to work with both stimulators and implanted pimps. Although, I know when I was getting ill, there were several companies developing new products and giving them a lot of competition.
Although, at the time we were a Center of Excellence and got referrals from surrounding states, at least 25% of our patient population had at least a portion of pain caused by this disorder. I have not recently done any research, but am sure if it was a VERY common problem in 1990-2010 it is even more common now. Look for Pain Management, Fellowship Trained pain physicians, and Google spinal cord stimulation therapy. Don’t give up, keep looking for help, and will keep you in my prayers, I am in no way diagnosing or recommending a particular treatment plan for you (medical disclosure) just giving you some information to investigate and research.
I do not think that any kind of opioid drugs will effective treat long term chronic pain because they do not address underlying causes. Pharmaceutical companies look for drugs they can patent to make a profit but the solutions will more likely come from other sources and therapies. I am currently having a good response to the supplement palmitoylethanolamide (PEA)for post exertion muscle pain. I have only been taking it for a couple of weeks so its too early to access its long term effectiveness. I am wondering if others with CFS/FMS have tried it? PEA is manufactured in the Netherlands and is available in the U.S. at peacure.com
As to statistics for opioid use and overdose… It would seem that much of the statistics quoted for death by use of prescription opioids makes no attempt to separate suicides (intentional overdose) from accidental overdose. Common sense suggests that many deaths are actually suicides for several reasons. People taking prescription drugs are well aware of the appropriate dosages which are usually considerably under toxic levels so even minor mistakes in taking the medication do not usually result in death. Secondly, people considering suicide who simply want to go to sleep and not wake up (as opposed to those who want to, or are willing to) jump off bridges or shoot themselves will consider opioids. In fact the opioid death might even be pleasant compared to most other methods readily available.
I also agree that opioids do not lose their effectiveness over time only the “high” (which is mostly just a sense of well-being) disappears. That’s what causes some people to constantly increase dosage.
It is unfortunate that those in government who lost the “war on Drugs” of the last three decades have found themselves a new war and have now taken up vilifying patients and doctors making legitimate use of the best painkiller currently available. Lots easier than wandering the jungles of Colombia trying to find armed armies of armed cocaine producers.
I have been taking Suboxone in a smaller dose than what is used for opioid addiction for the last few years and have found a great bit of relief from it. It’s an opioid antagonist. I think that may be 1 of the “new” meds they are referring to for trials in the future.
My mother have been suffering from fibromyalgia disease for the last 3 years and had constant pain, especially in her neck,During the first year,she had faith in God that she will be healed someday by the Almighty. This disease started circulate all over my moms body and she have been taking treatment from her doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (fibromyalgia) by this man DR Abumere and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to DR Abumere telling him about my mothers fibromyalgia disease he told me not to worry that my mom is gonna be okay with his herbal remedies!! actually i never believed it,, well after all the procedures and remedy given to me by this man i went to discuss it with my mom and explain everything to her on what she is about to take in,because Dr Abumere told me my mother must stop other medication just to make sure his own work properly,she agreed because this great doctor gave me assurance about his good work.
Weeks later after my mother start using this herbal medicine she started experiencing changes all over her as the DR assured me that she will cured,after some time i went to her doctor to confirmed if she has finally healed behold it was TRUE, So dear viewers my advise is if you have such sickness or any other at all you can email DR Abumere on: abumereherbalcentre @ gmail. com or visit his websit: www . abumereherbalcentre . simplesite . com
thank you doctor i will forever be grateful
Hi Cort,
I’m Maegan with Healthline, the fastest growing consumer health site on the web. Our mission is to make the world a stronger, healthier place by informing and uplifting.
One of the ways we do that is by sharing articles and information with health communities. One way we do that is by answering common questions that can help people improve the quality of their lives.
Our article about the causes of chronic pain details potential causes, treatments, and lifestyle remedies that can help people with chronic pain understand and treat their condition. We’ve gotten a lot of positive feedback that this article has helped those struggling with pain to find answers and effective solutions. You can read the article here:
http://www.healthline.com/health/chronic-pain
We would love it if you could share our article with your audience. We hope it will go a long way in helping those with chronic pain live happier, healthier lives.
If you have any questions, please feel free to reach out!
Warmly,
—
Maegan Jones | Content Coordinator
Healthline
Your most trusted ally in pursuit of health and well-being
Hi,
Nice article, thanks for sharing, keep up the good work
Maybe these drug companies should start donating money to my DRUG program ADAPT to save lives from the DEATH DRUG S they make and sell 20 billion is alot to lose and i have the CURE look me ☝
This is a good post. This post gives truly quality information. I’m definitely going to look into it here. Thank you so much
As doc said no more pills for me, getting too LOOPY went on Patch- Buprenorphine, since August 2018, worked up to 15 mcg, just didn’t do much for pain. Before that Norco, Tramadol started to make me loopy..now Only on 1/2 of 0.5 mg. SUB of suboxone, since one week, making me very dizzy, sometimes feel faint…doc says it will pass,but I’m in bed and dysfunctional..I’m d