People with fibromyalgia display an unusual activation in one of the most primordial parts of the brain - the brainstem. The activation involves giant neurons and likely increases pain sensitivity and impairs autonomic nervous system functioning.
An unusual one-shot, proof of concept Mestinon exercise trial in chronic fatigue syndrome stopped the energy drain and increased peak energy production.
The low levels of CO2 (hypocapnia) found during a NASA lean test in ME/CFS could be causing symptoms like fatigue, cognitive problems, sleep issues, tingling, etc.
Studies thus far indicate the long COVID and chronic fatigue syndrome (ME/CFS) may be exhausting the body in similar ways via viral persistence, autoimmunity, circulatory and blood issues and small fiber neuropathy.
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