Muscle pressures three times normal in fibromyalgia suggest that reduced blood flows to the muscle are causing pain and fatigue in FM. They also suggest that the central sensitization cannot explain everything in fibromyalgia.
Chronic fatigue syndrome and fibromyalgia show differing patterns of abnormal muscle activation - suggesting that one is caused by aerobic energy production problems and the other primarily by central nervous system problems.
Poor oxygen uptake from the red blood cells could help explain the exercise issues in chronic fatigue syndrome (ME/CFS). Mitochondrial problems or hyperventilation contribute to the oxygen uptake problem.
Besides the dozens of collaborators Tompkins has enrolled to support him in the Harvard ME/CFS Collaboration, Tompkins is seek to transform medical care there, and is engaged in muscle and exercise studies.
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