Takeaways From the Big Long COVID Clinical Trials

Takeaways From the Big Long COVID Clinical Trials

by | Apr 21, 2026 | Amytriptyline, Antivirals, CoQ10, COVID-19, Homepage, Inflammation, Ivabradine, Klimas, Lipids, long COVID, Mast cell activation syndrome, Microbiome, Orthostatic intolerance, Paxlovid, POTS, Treatment

Only 10 major long COVID clinical trials have been published thus far but that's enough to come away with some interesting takeaways. They include treatments that prevent long COVID don't necessarily treat it, broader based treatments are probably best, manipulating the gut can help with fatigue (but only so much), and an as yet unassessed class of drugs may be helpful.
Blood, Sex and Inflammation: Did the IMPACC Study Uncover Core Issues in Long COVID and ME/CFS?

Blood, Sex and Inflammation: Did the IMPACC Study Uncover Core Issues in Long COVID and ME/CFS?

by | Mar 5, 2026 | Baricitinib, Cardiovascular, Clotting, Complement, COVID-19, Endothelial Cells, Energy Production, Homepage, Hypoxia, Inflammation, Klimas, long COVID, Metabolism, Muscles, Oxidative Stress, Proteomics

The big IMPACC long COVID study findings suggest that inflammation and reduced male sex hormone levels may be playing havoc with the small blood vessels in long COVID -= and ME/CFS
“What’s Up, Doc?” Nancy Klimas on Viruses, ME/CFS’s Greatest Need, and Her ME/CFS Clinical Trial

“What’s Up, Doc?” Nancy Klimas on Viruses, ME/CFS’s Greatest Need, and Her ME/CFS Clinical Trial

by | Jan 10, 2025 | Antivirals, B-cells, Doctors, Epstein-Barr Virus, Etanercept, Homepage, Human Herpes Virus Six (HHV-6), Immune, Inflammation, Klimas, long COVID, Monoclonal antibodies, Pathogens, T-cells, Treatment

Dr. Nancy Klimas says what's exciting her most right now in the ME/CFS field is a renewed focus on herpesvirus reactivation and what artificial intelligence will bring.
The NIH on the ME/CFS Intramural Study -“Effort Preference”, Exhausted Immune Systems and the Crucial Male/Female Divide

The NIH on the ME/CFS Intramural Study -“Effort Preference”, Exhausted Immune Systems and the Crucial Male/Female Divide

by | Jun 2, 2024 | Autonomic Nervous System, B-cells, Brain, Brainstem, Cerebral Spinal Fluid, Conference Reports, Dopamine, Endoplasmic Reticulum, Energy Production, Gut, Homepage, Immune, Inflammation, Klimas, Lipids, Metabolism, Microbiome, Motor Cortex, Muscles, T-cells

The findings from a seminal (and massive) NIH intramural study done on chronic fatigue syndrome (ME/CFS) were explained during a symposium.
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