Talk about an oddball drug. Named after the earth smoke plant, dimethyl fumarate is an old compound used in industrial chemistry. Wikipedia reported that in 2012 you could get it for from $1 to $50 per metric ton (but you had to buy at least two tons of it)....
Chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) produce so many symptoms that diagnosing them can be difficult for uninformed doctors. While we know that small fiber polyneuropathy (SFPN) (or small fiber neuropathy (SFN) commonly occurs in both these diseases,...
Fibromyalgia, chronic fatigue syndrome and other functional pain disorders may triggered by an overactive fight/flight system which results in neuroinflammation.
Intranasal preparations could speed the delivery of drugs and supplements like glutathione and insulin to the brain in chronic fatigue syndrome and fibromyalgia and reduced inflammation there.
The authors propose that a new approach to fibromyalgia is needed to produce better drug treatments. They focused on cannabinoids, NMDA receptors, neuroinflammatory drugs, etc.
Two ME/CFS, yes, ME/CFS low dose naltrexone papers appear, one fibromyalgia report attempts to turn dosing protocols on their head, one patient blows through normal dose levels with spectacular success, Jarred Younger hunts for a more powerful naltrexone, and then...
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