AcH influenced
Member
After hitting bad times in various ways and not posting for a very long while (I have constantly been postponing this because I also have sort of a Writer's block problem, writing is a real problem for me) I just decided to simply post this and see where it goes :
The high levels of endogenous Acetaldehyde that I ( = the toxicology lab of course) have measured has a connection with a mast cell problem as a cause for all my disease symptoms. I have noticed that all my ME/CFS symptoms have an approximate level of severity with the severity of mast cell activation. That is : I seem to have a "background level" of mast cell mediators that are permanently produced and cause all my symptoms, I can vary this level a bit myself and notice the difference so I recognize how the system works.
The "half-drunkenness" I experienced and that I thought at first was solely caused by the acetaldehyde is actually most likely a combination of mast cell mediators and acetaldehyde. It is even possible that mast cell activation makes the acetaldehyde level rise because there is a common biological pathway involved. Very strong mast cell activation could have made it possible for me to measure the high acetaldehyde levels. So acetaldehyde either as an initiator of a mast cell process or as a product of a mast cell process or as involved in a bio chemical balanced state in all of this.
Things like POTS / balance problems, clumsiness, brainfog and general cognitive dysfunction well you get those things too if you are drunk of alcohol right ? It is the follow up effects of alcohol, the "half drunkenness" of the mast cell mediators / acetaldehyde that do that, the alcohol (ethanol) is only the substance that initiates this process. So with a bit of imagination you can see where a lot of the problems come from if the secondary part is constantly elevated without any alcohol at all....
It is in the alcohol intolerance (or at least differently reacting to it than before) that is also in general linear to the severity of the disease that the answer lies in for understanding ME/CFS, there are reasons why I measured high acetaldehyde levels.
It is also why Long Covid has the alcohol intolerance / different reaction to : you are likely looking at the same thing at work with the same cause, the amount of symptoms are too similar.
It all seems to be a mast cell problem that has gotten out of hand for some reason, for a lot of people like us this had a trigger and then it became permanent (just as in Long Covid)
Given my own experiences I believe now that, at the very minimum, the mast cell mediators/acetaldehyde is a big part of ME/CFS symptoms but it might even be the cause itself...
There is much more too say about this you have to excuse me if this process goes slowly, it is what it is and I don't like it either!
The high levels of endogenous Acetaldehyde that I ( = the toxicology lab of course) have measured has a connection with a mast cell problem as a cause for all my disease symptoms. I have noticed that all my ME/CFS symptoms have an approximate level of severity with the severity of mast cell activation. That is : I seem to have a "background level" of mast cell mediators that are permanently produced and cause all my symptoms, I can vary this level a bit myself and notice the difference so I recognize how the system works.
The "half-drunkenness" I experienced and that I thought at first was solely caused by the acetaldehyde is actually most likely a combination of mast cell mediators and acetaldehyde. It is even possible that mast cell activation makes the acetaldehyde level rise because there is a common biological pathway involved. Very strong mast cell activation could have made it possible for me to measure the high acetaldehyde levels. So acetaldehyde either as an initiator of a mast cell process or as a product of a mast cell process or as involved in a bio chemical balanced state in all of this.
Things like POTS / balance problems, clumsiness, brainfog and general cognitive dysfunction well you get those things too if you are drunk of alcohol right ? It is the follow up effects of alcohol, the "half drunkenness" of the mast cell mediators / acetaldehyde that do that, the alcohol (ethanol) is only the substance that initiates this process. So with a bit of imagination you can see where a lot of the problems come from if the secondary part is constantly elevated without any alcohol at all....
It is in the alcohol intolerance (or at least differently reacting to it than before) that is also in general linear to the severity of the disease that the answer lies in for understanding ME/CFS, there are reasons why I measured high acetaldehyde levels.
It is also why Long Covid has the alcohol intolerance / different reaction to : you are likely looking at the same thing at work with the same cause, the amount of symptoms are too similar.
It all seems to be a mast cell problem that has gotten out of hand for some reason, for a lot of people like us this had a trigger and then it became permanent (just as in Long Covid)
Given my own experiences I believe now that, at the very minimum, the mast cell mediators/acetaldehyde is a big part of ME/CFS symptoms but it might even be the cause itself...
There is much more too say about this you have to excuse me if this process goes slowly, it is what it is and I don't like it either!
![ME/CFS lecture | Dr Nancy Klimas | 2011 [Chronic Fatigue Syndrome / SEID / New Zealand] - YouTube](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
