Hi Cort, Yes, I've tried other ones, but I never got the same effect until I tried Primal Defense with the HSOs. Jordan Rubin who created this great product, just about died of Crohn's disease and HSO's was major in his recovery. I had read his book 'Patient heal thyself' a few years ago and decided to try it. Boy, what a miracle product. I must take it everyday otherwise the irritable bowel comes right back. I just googled Probiotics with HSO's and saw many articles on the subject that we can read. You can take up to 3 a day. I only need 1 capsule. Start with 1 only as too many can cause constipation.