I didn't know this medicine. So looked it up. Appears it would have a similar response as it ups histamine and dopamine, according to this article.
en.m.wikipedia.org
As of 2017, the therapeutic mechanism of action of modafinil for narcolepsy and sleep-wake disorders remains unknown.[35][36] Modafinil acts as an atypical, selective, and weak dopamine reuptake inhibitor which indirectly activates the release of orexin neuropeptides and histamine from the lateral hypothalamus and tuberomammillary nucleus, respectively all of which may contribute to heightened arousal.[35][36][37]
Dopamine transporter blocker Edit
Research found that modafinil elevates histamine levels in the hypothalamus in animals.[38] The locus of the monoamine action of modafinil was also the target of studies, with effects identified on dopamine in the striatum and, in particular, nucleus accumbens,[39][40] norepinephrine in the hypothalamus and ventrolateral preoptic nucleus,[41][42] and serotonin in the amygdala and frontal cortex.[43]
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An interesting recent finding of mine is that dopamine from D2R is what activates histamine especially in the brain. And carnosine helps up this histamine at the H3R, in the brain. AND, It also helps take down acetaldehyde. Which Dejurgen and I are researching and feel there is a strong connection with.
Brain monoamines (serotonin, norepinephrine, dopamine, and histamine) play an important role in emotions, cognition, and pathophysiology and treatment of mental disorders. The interactions between serotonin, norepinephrine, and dopamine were studied in numerous works; however, histamine system...
pubmed.ncbi.nlm.nih.gov
It can be concluded that histamine stimulates serotonin, norepinephrine, and dopamine transmission in the brain. Modulation of firing of dopamine neurons is a key element in functional interactions between histamine and other monoamines.
Histamine H[3] receptors are best known as presynaptic receptors inhibiting the release of histamine, as well as other neurotransmitters including acetylcholine and dopamine. However, in the dorsal and ventral striatum, the vast majority of H[3] receptors ...
www.ncbi.nlm.nih.gov
Tuning down GABA receptors. The H3R and D2 receptors wake you up and create dopamine. The D1 receptor creates GABA which is complete opposite effect and will make you sleepy.
So dopamine is turned on in the brain by the histamine receptor.
New research on genetically altered mice helps to untangle the complex interactions of GABA with brain systems necessary for sustaining wakefulness.
www.hypersomniafoundation.org
Histamine used for narcolepsy
The brain histamine system has been implicated in regulation of sensorimotor gating deficits and in Gilles de la Tourette syndrome (GTS). Histamine also regulates alcohol reward and consumption via H3 receptor (H3R), possibly through an interaction with the brain dopaminergic system. Here we...
jpet.aspetjournals.org
essential for the dopamine receptor-mediated signaling. In conclusion, these findings demonstrate that H3R is an important regulator of sensorimotor gating and the lack of H3R significantly modifies striatal dopaminergic signaling. These data support the usefulness of H3R ligands in neuropsychiatric disorders with pre-attentional deficits and disturbances in dopaminergic signaling.
****I havent read all of this one, but some good info here.*******
Talks about methylation and indicates issues with DAO and HNMT, both if which genetically I have too low function of. And that has to do with MCAS issues.