Isn't it true and kind of sad that what's worked best for me so far is pacing...I do take a lot of supplements as well, and will try new ones; I try these new ones for 3 months, and if they do nothing, I stop them. I do have a regime of supplements that I do take, not for a cure, but for maintenance. I do have moderately severe ME, and have improved over time, supplements ,and many different therapies have helped...however, I know what has helped the most, is proper pacing and rest..I will recommend the pacing protocol of Dr. Alison Bested[ from Toronto]..from her book"Chronic Fatigue Syndrome and Fibromyalgia"..I do not like the title..lol..but it was written in 2006...the best pacing protocol I have seen...she explains in length ,why..and the amount of energy the brain uses when engaged....difficult to do...yes...necessary...yes..always successful in doing...no..lol...best wishes to everyone...
I have found lots of things that helped but then my energy goes up and I crash (lol)